Dissolution profiles of flurbiprofen in phospholipid solid dispersions.

@article{Habib1998DissolutionPO,
  title={Dissolution profiles of flurbiprofen in phospholipid solid dispersions.},
  author={Muhammad J. Habib and Manh Tan Phan and Godfried Owusu-Ababio},
  journal={Drug development and industrial pharmacy},
  year={1998},
  volume={24 11},
  pages={1077-82}
}
This study is concerned with the development of a solid dispersion formulation of flurbiprofen (FLP) and phospholipid (PL) with improved dissolution characteristics. The FLP powders were blended with PL to produce FLP-PL physical mixtures or made into solid dispersions with PL by the solvent method. The FLP exhibited significantly improved dissolution rates in PL coprecipitate (coppt) compared to the physical mixtures or FLP alone. The dissolution studies suggested that less than a 20:1 ratio… CONTINUE READING

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