Dissolution of human cholesterol gallstones in stimulated chenodeoxycholate-rich and ursodeoxycholate-rich biles. An in vitro study of dissolution rates and mechanisms.

@article{Park1984DissolutionOH,
  title={Dissolution of human cholesterol gallstones in stimulated chenodeoxycholate-rich and ursodeoxycholate-rich biles. An in vitro study of dissolution rates and mechanisms.},
  author={Young Hak Park and Hirotsune Igimi and Martin C. Carey},
  journal={Gastroenterology},
  year={1984},
  volume={87 1},
  pages={150-8}
}
We have compared the kinetics and physical-chemical mechanisms of human cholesterol gallstone dissolution in simulated normal, chenodeoxycholate-rich, and ursodeoxycholate-rich " biles ." Owing to reduced micellar cholesterol solubilizing capacities, dissolution rates in ursodeoxycholate-rich biles were initially slower than in normal or chenodeoxycholate-rich biles . At later time points, dissolution rates in ursodeoxycholate-rich bile became accelerated; this was shown to be associated with… CONTINUE READING

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