Dissolution of beta2-microglobulin amyloid fibrils by dimethylsulfoxide.

  title={Dissolution of beta2-microglobulin amyloid fibrils by dimethylsulfoxide.},
  author={Nami Hirota-Nakaoka and Kazuhiro Hasegawa and Hironobu Naiki and Yuji Goto},
  journal={Journal of biochemistry},
  volume={134 1},
Increasing numbers of proteins have been found to aggregate into insoluble fibers, collectively referred to as amyloid fibrils. To address the conformational stability of amyloid fibrils, we studied the effects of dimethylsulfoxide (DMSO), 2,2,2-trifluoroethanol (TFE), and 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) on beta(2)-microglobulin amyloid fibrils by circular dichroism, thioflavin T fluorescence, light scattering, and electron microscopy. When measured by circular dichroism and thioflavin… CONTINUE READING
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