Dissolution kinetics for coprecipitates of diflunisal with PVP K30

  title={Dissolution kinetics for coprecipitates of diflunisal with PVP K30},
  author={C. Rodr{\'i}guez-Espinosa and Mar{\'i}a Cristina Mart{\'i}nez-Oh{\'a}rriz and Charles H. Martin and Mar{\'i}a Del Mar Go{\~n}i and Itziar V{\'e}laz and Miguel A. Sanchez},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
Diflunisal is a nonsteroidal anti-inflammatory drug that is poorly soluble in water. The present study describes the formulation of solid dispersions of the drug designed to increase its solubility. X-ray diffraction and DSC were used to examine the physico-chemical characteristics of solid dispersions of diflunisal and polyvinylpyrrolidone (PVP) prepared by the solvent method, using percentage proprtional compositions ranging from 20:80 to 50:50. X-ray diffraction analysis detected that… CONTINUE READING

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Publications referenced by this paper.
Showing 1-10 of 12 references

Dissolution properties of naproxen in combinations with polyvinylpyrrolidone

D. Bettinetti, P. Mura
Drug. Dev. Ind. Phann., • 1994

Thermal behaviour and physicochemical properties of naproxen in mixture with polyvinylpyrrolidone

P. Bettinetti D. Mura, F. Giordano, M. Setti
Thennochim. Acta, • 1991

Drug membrane transport enhancement using high energy drug polyvinylpirrolidone coprecipitates

0.1. Corrigan, M. A. Farvar, W. I. Higuchi
Int. J. Phann., • 1980

Drugpolyvinylpyrrolidone dispersions. A differential scanning calorimetric study

E. Shefter, K. C. Cheng
Int. J. Phann., • 1980

The influence of polyvinylpyrrolidone on the dissolution and bioavai/abi/ity of hydrochlorothiazide

Corrigan, Timoney R.F
J. Phann. Sci • 1975

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