Dissolution behaviour of sulphonamides into sodium dodecyl sulfate micelles: a thermodynamic approach.

  title={Dissolution behaviour of sulphonamides into sodium dodecyl sulfate micelles: a thermodynamic approach.},
  author={S Mall and Graham Buckton and David A. Rawlins},
  journal={Journal of pharmaceutical sciences},
  volume={85 1},
The surface energies of four sulfonamides have been assessed from contact angle data, using the Lewis acid-base approach. From these data the free energy of adhesion between the drugs and sodium dodecyl sulfate (SDS) head groups and tails has been calculated. The most favored interaction was for adhesion to the SDS tails, rather than the head groups. The initial rotating disk dissolution rate (hereafter termed dissolution rate) of drug compacts has been measured in water and water with SDS… CONTINUE READING

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