Dissolution Improvement and the Mechanism of the Improvement from Cocrystallization of Poorly Water-soluble Compounds

@article{Shiraki2008DissolutionIA,
  title={Dissolution Improvement and the Mechanism of the Improvement from Cocrystallization of Poorly Water-soluble Compounds},
  author={Koji Shiraki and Noriyuki Takata and Ryusuke Takano and Yoshiki Hayashi and Katsuhide Terada},
  journal={Pharmaceutical Research},
  year={2008},
  volume={25},
  pages={2581-2592}
}
PurposeTo demonstrate improvement in the dissolution of exemestane and megestrol acetate from cocrystallization using various particle sizes and to investigate the mechanism of the improved dissolution.MethodsCocrystal screening was performed by slurry crystallization. The cocrystals were identified and characterized by powder X-ray diffraction, thermal analysis, and single crystal X-ray diffraction. Different particle sizes of each cocrystal were prepared from organic solutions. Solubility and… 
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