Dissociative reactions of benzonorbornadienes with tetrazines: scope of leaving groups and mechanistic insights.

Abstract

Bioorthogonal dissociative reactions boast diverse potential applications in chemical biology and drug delivery. The reaction of benzonorbornadienes with tetrazines to release amines from carbamate leaving groups was recently introduced as a bioorthogonal bond-cleavage reaction. The present study aimed at investigating the scope of leaving groups that are… (More)
DOI: 10.1039/c7ob02191g

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