Dissociative Anesthesia: Further Pharmacologic Studies and First Clinical Experience with the Phencyclidine Derivative Cl‐581

@article{Corssen1966DissociativeAF,
  title={Dissociative Anesthesia: Further Pharmacologic Studies and First Clinical Experience with the Phencyclidine Derivative Cl‐581},
  author={Guenter Corssen and Edward F. Domino},
  journal={Anesthesia \& Analgesia},
  year={1966},
  volume={45},
  pages={29–40}
}
HERE IS A definite need for safe and T potent intravenously administered anesthetics of short duration which combine analgesic and sleep-producing effects without significant cardiovascular and respiratory depression. Recently, a number of compounds related to phenylcyclohexylamine have aroused clinical interest because they appear to approach such requirements. Phencyclidine hydrochloride was the prototype of this group of agents. After preliminary laboratory studies1 its clinical usefulness… 

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References

SHOWING 1-7 OF 7 REFERENCES
Visually Evoked Responses in Man: A Method for Measuring Cerebral Effects of Preanesthetic Medication
TLDR
Of the various muscarinic cholingcric blocking agents employed, scopolnmine hydrobromide proved to be most effective in altering the VER while its Quaternary analogue, methscopolamine, which is known to penetrate the blood-brain barrier with difficulty, had no significant effect.
The pharmacology of 1-(1-phenylcyclohexyl) piperidine-HCl.
TLDR
PCP is very effective in abolishing the electrically-or pentylenetetrazol-induced tonic-extensor seizures in mice, is slightly effective in suppressing caffeine-induced seizures but ineffective against those induced by strychnine.
General Anesthetic Action of Z-(O-chlorophenyl) 2-methylaminocyclohexanone HCl (CI-581) in the Rhesus Monkey
  • Fed. Proc. 24:268,
  • 1965
Human Pharmacologic Effects of CI-581, a Phencyclidine Derivative
  • J. Clin. Pharmacol
  • 1965