Dissociative Anesthesia: Further Pharmacologic Studies and First Clinical Experience with the Phencyclidine Derivative Cl‐581

  title={Dissociative Anesthesia: Further Pharmacologic Studies and First Clinical Experience with the Phencyclidine Derivative Cl‐581},
  author={Guenter Corssen and Edward F. Domino},
  journal={Anesthesia \& Analgesia},
HERE IS A definite need for safe and T potent intravenously administered anesthetics of short duration which combine analgesic and sleep-producing effects without significant cardiovascular and respiratory depression. Recently, a number of compounds related to phenylcyclohexylamine have aroused clinical interest because they appear to approach such requirements. Phencyclidine hydrochloride was the prototype of this group of agents. After preliminary laboratory studies1 its clinical usefulness… 

Figures and Tables from this paper

Effects of Two New Dissociative Anesthetic Agents, Ketamine and CL‐1848C, on the Respiratory Response to Carbon Dioxide
The term “dissociative anesthesia” was used to describe the anesthetic state characteristic of both drugs, and ketamine acts rapidly, on intravenous or intramuscular administration, to produce a state characterized by catalepsy, analgesia, and amnesia.
Clinical studies of induction agents. XXXVI: Ketamine.
The intravenous anaesthetic ketamine has been given to patients undergoing minor gynaecological surgery after atropine prcmedication in initial doses ranging from 1.0 to 3.0 mg/kg, with a high incidence of delirium at all dose levels.
Evaluation of CL‐1848C: A New Dissociative Anesthetic in Normal Human Volunteers
From the observations and personal experience, it was felt that the investigation of a new drug, CL-1848C, from Cutter Laboratories, must be approached as a multidisciplinary problem.
Pharmacological Aspects and Potential New Clinical Applications of Ketamine: Reevaluation of an Old Drug
Reevaluation, though, of analgesic properties of ketamine resulted in new interest regarding its use in perioperative and chronic pain management and recent studies in the effects of the substance on intracranial pressure and cerebral blood flow led to revising the recommendation against itsUse in brain injury.
Intravenous Sedatives and Anesthetics
This chapter discusses the pharmacology of frequently used intravenous hypnotic drugs in geriatric patients. The uses as well as cautions regarding the administration of propofol, thiopental,
Comparison of Ketamine and Methohexital as Induction Agents for Methoxyflurane Anesthesia
Although recommended as an induction agent for general anesthesia, experimental studies in support of this recommendation are lacking,oretically, ketamine could possibly hasten the uptake and distribution of the anesthetic agent by virtue of its stimulant actions.
The term “dissociative anesthesia” is introduced to describe the unique anesthetic state produced by ketamine, a unique state of unconsciousness in which the patient is in a cataleptic trance-like state, disconnected from the surrounding environment, and apparently profoundly analgesic.
Use of Ketamine as Monoanesthetic in Clinical Anesthesia, Acid-Base Status and Oxygenation
In order to evaluate the drug as completely as possible, only interventions in which CI-581 could be used as mono-anesthetic were anticipated.
Anesthesia With Ketamine: Indications, Advantages, and Shortcomings
It is now desirable to inquire into such matters as the indications for the use of this drug in preference to other anesthetic agents, its advantages, and its shortcomings.


Visually Evoked Responses in Man: A Method for Measuring Cerebral Effects of Preanesthetic Medication
Of the various muscarinic cholingcric blocking agents employed, scopolnmine hydrobromide proved to be most effective in altering the VER while its Quaternary analogue, methscopolamine, which is known to penetrate the blood-brain barrier with difficulty, had no significant effect.
The pharmacology of 1-(1-phenylcyclohexyl) piperidine-HCl.
PCP is very effective in abolishing the electrically-or pentylenetetrazol-induced tonic-extensor seizures in mice, is slightly effective in suppressing caffeine-induced seizures but ineffective against those induced by strychnine.
General Anesthetic Action of Z-(O-chlorophenyl) 2-methylaminocyclohexanone HCl (CI-581) in the Rhesus Monkey
  • Fed. Proc. 24:268,
  • 1965
Human Pharmacologic Effects of CI-581, a Phencyclidine Derivative
  • J. Clin. Pharmacol
  • 1965