Dissociations between the effects of hallucinogens on behavior and raphe unit activity in behaving cats

@article{Trulson1986DissociationsBT,
  title={Dissociations between the effects of hallucinogens on behavior and raphe unit activity in behaving cats},
  author={M. Trulson},
  journal={Pharmacology Biochemistry and Behavior},
  year={1986},
  volume={24},
  pages={351-357}
}
  • M. Trulson
  • Published 1986
  • Medicine, Psychology
  • Pharmacology Biochemistry and Behavior
The hypothesis that hallucinogenic drugs exert their behavioral effects by an action at pre- or postsynaptic serotonin receptors was evaluated by co-administering various drugs that possess either serotonin agonist or antagonist properties, while concurrently monitoring behavior and the electrophysiological activity of serotonin-containing dorsal and median raphe neurons in freely moving cats. Co-administration of the serotonin receptor blockers, metergoline or mianserin, with lysergic acid… Expand
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Dissociations between the effects of hallucinogenic drugs on behavior and raphe unit activity in freely moving cats
TLDR
The serotonin hypothesis of hallucinogenic drug action should be re-evaluated and the phenylethylamine hallucinogens may exert a depressant effect upon a subset of serotonin-containing neurons, and an amphetamine-like excitatory effect upon another subset of these neurons. Expand
Differential effects of hallucinogenic drugs on the activity of serotonin-containing neurons in the nucleus centralis superior and nucleus raphe pallidus in freely moving cats.
TLDR
The data suggest that ascending dorsal raphe and NCS neurons may be involved in the process of hallucinogenesis, whereas descending RPA neurons do not appear to beinvolved in this process. Expand
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Dissociations between the effects of LSD on behavior and raphe unit activity in freely moving cats.
The hypothesis that the action of hallucinogenic drugs is mediated by a depression of the activity of brain serotonergic (raphe) neurons was tested by examining the behavioral effects of d-lysergicExpand
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: Previously, d-lysergic acid diethylamide was found to have a more powerful inhibitory action upon serotonergic (raphe) neurons than upon neurons in areas receiving an identified serotonergic inputExpand
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