Dissociations between cognitive and motor effects of psychostimulants and atomoxetine in hyperactive DAT-KO mice

@article{DelGuidice2013DissociationsBC,
  title={Dissociations between cognitive and motor effects of psychostimulants and atomoxetine in hyperactive DAT-KO mice},
  author={Thomas Del’Guidice and Morgane Lemasson and Adeline Eti{\'e}vant and Stella Manta and Luiz Alexandre V. Magno and Guy Escoffier and François S Roman and Jean-Martin Beaulieu},
  journal={Psychopharmacology},
  year={2013},
  volume={231},
  pages={109-122}
}
Psychostimulants such as amphetamine and methylphenidate, which target the dopamine transporter (DAT), are the most frequently used drugs for the treatment of hyperactivity and cognitive deficits in humans with attention deficit hyperactivity disorder (ADHD). While psychostimulants can increase activity in healthy subjects, they exert a “paradoxical” calming effect in humans with ADHD as well as in hyperactive mice lacking the dopamine transporter (DAT-KO mice). However, the mechanism of action… CONTINUE READING

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