Dissociation of vasospasm and secondary effects of experimental subarachnoid hemorrhage by clazosentan.

@article{Sabri2011DissociationOV,
  title={Dissociation of vasospasm and secondary effects of experimental subarachnoid hemorrhage by clazosentan.},
  author={Mohammed Sarwar Sabri and Jinglu Ai and Robert L Macdonald},
  journal={Stroke},
  year={2011},
  volume={42 5},
  pages={1454-60}
}
BACKGROUND AND PURPOSE Endothelin receptor antagonists such as clazosentan decrease large-artery vasospasm after experimental and clinical subarachnoid hemorrhage. We used clazosentan to gain insight into the pathophysiology of subarachnoid hemorrhage by determining if decreasing vasospasm is associated with alleviation of other secondary complications of subarachnoid hemorrhage such as oxidative stress, endothelial nitric oxide synthase dysfunction, microthromboembolism, and neuronal injury… CONTINUE READING