Dissociation of two signals required for activation of resting B cells.

@article{Julius1982DissociationOT,
  title={Dissociation of two signals required for activation of resting B cells.},
  author={Michael H. Julius and Harald von Boehmer and Charles L. Sidman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1982},
  volume={79 6},
  pages={1989-93}
}
Cellular interactions involved in the T cell-dependent activation of B cells were analyzed by using lines and clones of helper T cells specific for determinants expressed on the B cell surface. Activation of male antigen-, M locus-, and H-2-specific T cells was shown to support polyclonal Ig production by a population of B cells that did not require T-cell-B-cell interaction for induction/amplification. However, these T cells alone did not activate gradient-purified small (resting) B cells. The… CONTINUE READING