Dissociation of serum dehydroepiandrosterone and dehydroepiandrosterone sulfate in septic shock.

Abstract

CONTEXT Dehydroepiandrosterone (DHEA) replacement in sepsis has been advocated because of the sepsis-associated decrease in serum DHEA sulfate (DHEAS). However, experimental sepsis in rodents leads to down-regulation of DHEA sulfotransferase, which inactivates DHEA to DHEAS, theoretically resulting in higher DHEA levels. OBJECTIVE The objective of the… (More)