Dissociation of radiation-induced phosphorylation of replication protein A from the S-phase checkpoint.

@article{Morgan1997DissociationOR,
  title={Dissociation of radiation-induced phosphorylation of replication protein A from the S-phase checkpoint.},
  author={Susan E. Morgan and Michael B. Kastan},
  journal={Cancer research},
  year={1997},
  volume={57 16},
  pages={3386-9}
}
Replication protein A (RPA) is a trimeric single-stranded DNA-binding protein complex involved in DNA replication, repair, and recombination. DNA damage induces phosphorylation of the RPA p34 subunit, and it has been speculated that this phosphorylation could contribute to the regulation of the DNA damage-induced S-phase checkpoint. To further examine this potential relationship, human cell lines expressing ataxia telangiectasia (AT)-mutated dominant-negative fragments, which fail to arrest in… CONTINUE READING
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Phosphorylation of the p 34 subunit of human single - stranded DNA - binding protein in cyclin A - activated G , extracts is catalyzed by cdk - cyclin A complex and DNA - dependent protein complex

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