Dissociation of parathyroid hormone bioactivity and immunoreactivity in pseudohypoparathyroidism type I.

@article{Deuxchaisnes1981DissociationOP,
  title={Dissociation of parathyroid hormone bioactivity and immunoreactivity in pseudohypoparathyroidism type I.},
  author={C N de Deuxchaisnes and Jan A. Fischer and Maximilian A. Dambacher and J. P. Devogelaer and C E Arber and Joan M. Zanelli and Jonathan A. Parsons and Nigel Loveridge and Lucille Bitensky and J. Chayen},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1981},
  volume={53 6},
  pages={1105-9}
}
Circulating levels of parathyroid hormone (PTH) in six patients with pseudohypoparathyroidism type I (PSPI) have been measured by two immunoassays and by cytochemical bioassay and compared with measurements in normal subjects and patients with clinically defined hyper- and hypoparathyroidism. In all PSPI patients, the levels of immunoreactive PTH were in the hyperparathyroid range, whereas the bioactive levels were either in the normal or close to the normal range. In one patient from whom the… CONTINUE READING