Dissociation of osteogenic and immunological effects by the selective glucocorticoid receptor agonist, compound A, in human bone marrow stromal cells.

@article{Rauner2011DissociationOO,
  title={Dissociation of osteogenic and immunological effects by the selective glucocorticoid receptor agonist, compound A, in human bone marrow stromal cells.},
  author={Martina Rauner and Claudia Goettsch and Nicola C. G. Stein and Sylvia Thiele and Martin Bornhaeuser and Karolien De Bosscher and Guy Haegeman and Jan P Tuckermann and Lorenz Christian Hofbauer},
  journal={Endocrinology},
  year={2011},
  volume={152 1},
  pages={103-12}
}
Glucocorticoids (GCs) regulate various physiological processes, including bone remodeling. Whereas physiological amounts of GCs are required for proper human osteoblast differentiation, prolonged exposure to GCs leads to substantial bone loss in vivo predominantly by inhibiting osteoblast functions. Compound A (CpdA) is a novel GC receptor modulator with the potential of an improved benefit/risk profile. Here we tested the osteoimmunological effects of CpdA on primary human osteoblasts and… CONTINUE READING

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