Dissociation of nuclear and cytoplasmic cell cycle progression by drugs employed in cell synchronization.

@article{Urbani1995DissociationON,
  title={Dissociation of nuclear and cytoplasmic cell cycle progression by drugs employed in cell synchronization.},
  author={Lenore Urbani and Steven W. Sherwood and Robert T. Schimke},
  journal={Experimental cell research},
  year={1995},
  volume={219 1},
  pages={159-68}
}
We have studied the effect of the cell synchronization agents compactin, ciclopirox olamine, mimosine, aphidicolin, ALLN, and colcemid on several parameters of cell cycle progression in mitotically synchronized HeLa S3 cells. Using cell size and cyclin A and B levels as markers of cytoplasmic progression and DNA content as a measure of nuclear cell cycle position, we have examined coordination of cytoplasmic and nuclear events during induction synchrony. Each synchronizing agent was unique in… CONTINUE READING
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