Dissociation of mitochondrial depolarization from cytochrome c release during apoptosis induced by photodynamic therapy

Abstract

Photodynamic therapy (PDT) with the phthalocyanine photosensitizer Pc 4 induces rapid apoptosis in mouse lymphoma (LY-R) cells, initiating with the release of cytochrome c from mitochondria. It has been proposed that the opening of the mitochondrial membrane permeability transition pores, which results in the dissipation of the mitochondrial membrane… (More)
DOI: 10.1054/bjoc.2000.1714

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