Dissociation of metabolic and neurovascular responses to levodopa in the treatment of Parkinson's disease.

@article{Hirano2008DissociationOM,
  title={Dissociation of metabolic and neurovascular responses to levodopa in the treatment of Parkinson's disease.},
  author={Shigeki Hirano and Kotaro Asanuma and Yilong Ma and Chengke Tang and Andrew S Feigin and Vijay Dhawan and M. Carbon and David Eidelberg},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 16},
  pages={4201-9}
}
We compared the metabolic and neurovascular effects of levodopa (LD) therapy for Parkinson's disease (PD). Eleven PD patients were scanned with both [15O]-H2O and [18F]-fluorodeoxyglucose positron emission tomography in the unmedicated state and during intravenous LD infusion. Images were used to quantify LD-mediated changes in the expression of motor- and… CONTINUE READING
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