Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers.

@article{Tsai2006DissociationOL,
  title={Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers.},
  author={Amy G. Tsai and Pedro J. Cabrales and Belur N. Manjula and Seetharama A. Acharya and Robert M. Winslow and Marcos Intaglietta},
  journal={Blood},
  year={2006},
  volume={108 10},
  pages={3603-10}
}
Cell-free hemoglobin's (CFH) high affinity for nitric oxide (NO) could limit CFH's use as an oxygen-carrying blood replacement fluid because it scavenges NO, causing vasoconstriction and hypertension. However, the extent to which perivascular NO levels change following intravascular administration of hemoglobin (Hb) with different molecular dimensions correlates with vasoconstrictive responses in the microcirculation is unknown. The study objective was to determine vasoconstrictive effects… CONTINUE READING
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