Dissociation of glucocorticoid inhibition of glucose transport and metabolism by increase in adipocyte age and/or size.

Abstract

Exposure of adipocytes from young rats (2--3 months old) to dexamethasone in vitro results in 40--50% inhibition of glucose transport and metabolism. Comparable experiments with older rats reveal that the hormonal effect on glucose metabolism is progressively reduced to about 20% in 12- to 13-month-old animals and about 5% in 24- to 26-month-old animals… (More)

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