Dissociation of function between the dorsal and the ventral hippocampus in spatial learning abilities of the rat: a within‐subject, within‐task comparison of reference and working spatial memory

@article{Pothuizen2004DissociationOF,
  title={Dissociation of function between the dorsal and the ventral hippocampus in spatial learning abilities of the rat: a within‐subject, within‐task comparison of reference and working spatial memory},
  author={Helen H. J. Pothuizen and Weining Zhang and Ana L{\'u}cia Jongen-R{\^e}lo and Joram Feldon and Benjamin K Yee},
  journal={European Journal of Neuroscience},
  year={2004},
  volume={19}
}
Lesions restricted to the dorsal, but not the ventral, hippocampus severely impair the formation of spatial memory. This dissociation was first demonstrated using the water maze task. The present study investigated whether the dorsal and the ventral hippocampus are involved differentially in spatial reference and spatial working memory using a four‐baited/four‐unbaited version of the eight‐arm radial maze task. This test allows the concurrent evaluation of reference and working memory with… 
Small lesions of the dorsal or ventral hippocampus subregions are associated with distinct impairments in working memory and reference memory retrieval, and combining them attenuates the acquisition rate of spatial reference memory.
TLDR
Taken together, both dorsal and ventral poles of the hippocampus contribute to efficient spatial navigation in mice: While the integrity of dorsal hippocampus is necessary for spatial working memory, the acquisition and retrieval of spatial reference memory are modulated by the ventral hippocampus.
A study of hippocampal structure‐function relations along the septo‐temporal axis
TLDR
The finding that selective lesions limited to the intermediate zone of the hippocampus produce no impairment in either WM (“rapid place learning”) or RM in the authors' radial maze tasks serve to limit the generality of the conclusion of Bast et al. ( 2009 ) that the intermediate area is needed for behavioral performance based on rapid learning about spatial cues.
Performance on spatial working memory tasks after dorsal or ventral hippocampal lesions and adjacent damage to the subiculum.
TLDR
A volumetric analysis of subicular damage showed that dorsal hippocampal lesions caused a deficit in the non-matching-to-place procedure in the T maze only when accompanied by damage to the dorsal subiculum; on the other hand, lesions toThe dorsal hippocampus impaired performance in the radial-arm maze regardless of the extent ofSubicular damage.
Flexible spatial learning requires both the dorsal and ventral hippocampus and their functional interactions with the prefrontal cortex
TLDR
Investigating circuit mechanisms by temporarily inactivating the medial PFC, the dorsal HPC, and the ventral HPC as rats learned spatial discriminations and reversals in a plus maze found that flexible spatial learning depends on both the dHPC and vH PC and their functional interactions with the mPFC.
Transient Inactivation of the Medial Prefrontal Cortex and Ventral Hippocampus Impairs Active Place Avoidance Retrieval on a Rotating Arena
TLDR
The results showed not only bilateral inactivations of either structure, but also the combined inActivations impaired the retrieval of spatial memory, whereas unilateral one-structure inactivation did not yield any effect.
Contributions of the dorsal hippocampus and the dorsal subiculum to processing of idiothetic information and spatial memory
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References

SHOWING 1-10 OF 32 REFERENCES
The effects of NMDA‐induced retrohippocampal lesions on performance of four spatial memory tasks known to be sensitive to hippocampal damage in the rat
Four separate cohorts of rats were employed to examine the effects of cytotoxic retrohippocampal lesions in four spatial memory tasks which are known to be sensitive to direct hippocampal damage
Double dissociation of function within the hippocampus: a comparison of dorsal, ventral, and complete hippocampal cytotoxic lesions.
TLDR
Rats with complete cytotoxic hippocampal lesions exhibited spatial memory impairments in both the water maze and elevated T maze and were less efficient on a nonspatial, differential reinforcement of low rates (DRL) task.
Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions
  • E. Moser, MB Moser, P. Andersen
  • Biology, Psychology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1993
TLDR
The dorsal half of the hippocampus appears more important for spatial learning than the ventral half, with a threshold at about 20% of the total hippocampal volume, under which normal learning can occur.
Double dissociation of function within the hippocampus: spatial memory and hyponeophagia.
TLDR
Results show a double dissociation between dorsal and ventral hippocampal lesions (hyponeophagia vs. spatial memory), suggesting differentiation of function along the septotemporal axis of this structure.
Effects of medial septal or unilateral hippocampal inactivations on reference and working spatial memory in rats
TLDR
The memory performances of rats receiving a reversible inactivation of either the medial septum or one side of the ventral hippocampus were compared in a radial arm maze task allowing the assessment of both working and reference memory, suggesting that the septo‐hippocampal formation acts as a functionally homogeneous structure essential for spatial processing.
Dissociating context and space within the hippocampus: effects of complete, dorsal, and ventral excitotoxic hippocampal lesions on conditioned freezing and spatial learning.
TLDR
Rats with complete excitotoxic hippocampal lesions or selective damage to the dorsal or ventral hippocampus were compared with controls on measures of contextually conditioned freezing in a signaled shock procedure and on a spatial water-maze task; the partial lesion effects seen in the 2 tasks never resembled each other.
On the role of the hippocampus in learning and memory in the rat.
  • L. Jarrard
  • Biology, Psychology
    Behavioral and neural biology
  • 1993
A Within-Subjects, Within-Task Demonstration of Intact Spatial Reference Memory and Impaired Spatial Working Memory in Glutamate Receptor-A-Deficient Mice
TLDR
Two experiments provide additional evidence of a selective spatial WM deficit coexisting with intact spatial RM acquisition in GluRA−/− mice, suggesting that different neuronal mechanisms within the hippocampus may support these different kinds of information processing.
Longitudinal axis of the hippocampus: Both septal and temporal poles of the hippocampus support water maze spatial learning depending on the training protocol
TLDR
The results suggest that the temporal hippocampus can support the learning of two, but also one, spatial water maze reference memory task, provided the training protocol is adequate.
Functional differentiation in the hippocampus
TLDR
In primates, the posterior hippocampus (corresponding to the dorsal hippocampus of rodents) appears to be more important than anterior areas for encoding of spatial memory and certain forms of nonspatial memory.
...
1
2
3
4
...