Dissociation of food and opiate preference by a genetic mutation in zebrafish.

@article{Lau2006DissociationOF,
  title={Dissociation of food and opiate preference by a genetic mutation in zebrafish.},
  author={Billy Y B Lau and Sandrine Bretaud and Yanzhou Huang and Elaine Lin and Su Guo},
  journal={Genes, brain, and behavior},
  year={2006},
  volume={5 7},
  pages={497-505}
}
Both natural rewards and addictive substances have the ability to reinforce behaviors. It has been unclear whether identical neural pathways mediate the actions of both. In addition, little is known about these behaviors and the underlying neural mechanisms in a genetically tractable vertebrate, the zebrafish Danio rerio. Using a conditioned place preference paradigm, we demonstrate that wildtype zebrafish exhibit a robust preference for food as well as the opiate drug morphine that can be… CONTINUE READING

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