Dissociation of dopamine release in the nucleus accumbens from intracranial self-stimulation

@article{Garris1999DissociationOD,
  title={Dissociation of dopamine release in the nucleus accumbens from intracranial self-stimulation},
  author={Paul Garris and Michaux Kilpatrick and Melissa A. Bunin and Darren J Michael and Quintisha Walker and R Mark Wightman},
  journal={Nature},
  year={1999},
  volume={398},
  pages={67-69}
}
Mesolimbic dopamine-releasing neurons appear to be important in the brain reward system,. One behavioural paradigm that supports this hypothesis is intracranial self-stimulation (ICS), during which animals repeatedly press a lever to stimulate their own dopamine-releasing neurons electrically. Here we study dopamine release from dopamine terminals in the nucleus accumbens core and shell in the brain by using rapid-responding voltammetric microsensors during electrical stimulation of dopamine… CONTINUE READING