Dissociation of coronary vascular tolerance and neurohormonal adjustments during long-term nitroglycerin therapy in patients with stable coronary artery disease.

@article{Mnzel1996DissociationOC,
  title={Dissociation of coronary vascular tolerance and neurohormonal adjustments during long-term nitroglycerin therapy in patients with stable coronary artery disease.},
  author={Thomas F. M{\"u}nzel and Thomas Heitzer and Stefan Kurz and David G Harrison and Cindie M Luhman and Lars Pape and M. Olschewski and Hanjorg Just},
  journal={Journal of the American College of Cardiology},
  year={1996},
  volume={27 2},
  pages={297-303}
}
OBJECTIVES We sought to examine whether long-term nitroglycerin treatment causes tolerance in large coronary arteries and whether the loss of vascular effects parallels neurohormonal adjustments. BACKGROUND Nitroglycerin therapy is associated with increased plasma renin activity and aldosterone levels and a decrease in hematocrit. It is assumed that nitroglycerin tolerance results in part from these neurohormonal adjustments and intravascular volume expansion. METHODS Three groups were… CONTINUE READING