Dissociation of co-regulatory control of debrisoquin/phenformin and sparteine oxidation in Ghanaians.

@article{Woolhouse1985DissociationOC,
  title={Dissociation of co-regulatory control of debrisoquin/phenformin and sparteine oxidation in Ghanaians.},
  author={Norman Woolhouse and Michel F Eichelbaum and Nicola Oates and Jeffrey R Idle and Robert L. Smith},
  journal={Clinical pharmacology and therapeutics},
  year={1985},
  volume={37 5},
  pages={512-21}
}
The ability to oxidize sparteine to form 2- and 5-dehydrosparteine was studied in 154 healthy Ghanaians. Although the urinary metabolic sparteine/dehydrosparteines ratio varied widely (from 0.14 to 12.5), in contrast to observations in several Caucasian population groups the ratios were not bimodally distributed and no phenotypically poor oxidizers of sparteine were found. The ability of these same subjects to oxidize debrisoquin and phenformin was also studied in 141 and 143 subjects. Of the… CONTINUE READING