Dissociation of behavioral changes in rats resulting from lesions of the habenula versus fasciculus retroflexus and their possible anatomical substrates.

@article{Thornton1994DissociationOB,
  title={Dissociation of behavioral changes in rats resulting from lesions of the habenula versus fasciculus retroflexus and their possible anatomical substrates.},
  author={Everard W. Thornton and Marion Murray and T Connors-Eckenrode and Forrest Haun},
  journal={Behavioral neuroscience},
  year={1994},
  volume={108 6},
  pages={1150-62}
}
Lesions in either the habenula or its primary efferent pathway, the fasciculus retroflexus (FR), impaired avoidance responding. However, lesions of only the FR provided a persistent elevation of locomotor activity. Immunocytochemical study of the interpeduncular nucleus (IPN) through injection of retrograde tracers into the IPN and the overlying ventral tegmental area indicated that habenular lesions spared both rostral habenula and forebrain projections to the caudal midbrain, but these… CONTINUE READING

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