Dissociation of antithrombotic effect and bleeding time prolongation in rabbits by inhibiting tissue factor function.

@article{Himber1997DissociationOA,
  title={Dissociation of antithrombotic effect and bleeding time prolongation in rabbits by inhibiting tissue factor function.},
  author={Jacques Himber and Daniel Kirchhofer and Monika Riederer and Thomas B. Tschopp and Beat Steiner and Serge Roux},
  journal={Thrombosis and haemostasis},
  year={1997},
  volume={78 3},
  pages={1142-9}
}
Inhibition of the tissue factor/factor VIIa (TF/F.VIIa) complex attenuates thrombosis in different animal models of arterial thrombosis. However, it remains unclear to what extent the antithrombotic effects are associated with changes in hemostatic functions and how this compares with inhibition of thrombin, an enzyme acting at a later stage in the coagulation cascade. The antithrombotic and the antihemostatic effects of a monoclonal anti-TF antibody (AP-1) were compared in a model of arterial… CONTINUE READING

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