Dissociation of IGF2 and H19 imprinting in human brain

@article{Pham1998DissociationOI,
  title={Dissociation of IGF2 and H19 imprinting in human brain},
  author={N. V. Pham and M. T. Nguyen and J. Hu and T. Vu and A. Hoffman},
  journal={Brain Research},
  year={1998},
  volume={810},
  pages={1-8}
}
The human IGF2 and H19 genes are imprinted in most normal tissues. Alterations of genomic imprinting or loss of imprinting (LOI) have been observed in a number of malignant tumors. Although LOI has been linked to tumorigenesis, loss of IGF2 imprinting has also been observed in choroid plexus and leptomeninges in normal mouse brain. We have therefore analyzed the allelic expression of both IGF2 and H19 in human fetal brain and in different regions of human adult brain. In the brains of fetuses… Expand
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