Dissociation of ERK and Akt signaling in endothelial cell angiogenic responses to beta-amyloid.

@article{Magran2006DissociationOE,
  title={Dissociation of ERK and Akt signaling in endothelial cell angiogenic responses to beta-amyloid.},
  author={Jordi Magran{\'e} and Rial A Christensen and K. M. Rosen and Vimal Veereshwarayya and Henry W. Querfurth},
  journal={Experimental cell research},
  year={2006},
  volume={312 7},
  pages={996-1010}
}
Cerebrovascular deposits of beta-amyloid (Abeta) peptides are found in Alzheimer's disease and cerebral amyloid angiopathy with stroke or dementia. Dysregulations of angiogenesis, the blood-brain barrier and other critical endothelial cell (EC) functions have been implicated in aggravating chronic hypoperfusion in AD brain. We have used cultured ECs to model the effects of beta-amyloid on the activated phosphorylation states of multifunctional serine/threonine kinases since these are… CONTINUE READING