Dissociation of Ca2+ mobilization from breakdown of phosphatidylinositol 4,5-bisphosphate in activated human platelets.

@article{Kito1986DissociationOC,
  title={Dissociation of Ca2+ mobilization from breakdown of phosphatidylinositol 4,5-bisphosphate in activated human platelets.},
  author={Makoto Kito and Hiroshi Narita and Hitoshi Takamura and Hyen Joo Park and Takanori Matsuura and Katsunori Tanaka},
  journal={Journal of biochemistry},
  year={1986},
  volume={99 4},
  pages={1277-80}
}
The early breakdown of phosphatidylinositol 4,5-bisphosphate in human platelets stimulated by a threshold concentration of either collagen or thrombin was inhibited by 5 mM NaF through its inhibition of phospholipase C activity. However, 5 mM NaF did not inhibit Ca2+ mobilization due to the stimuli from internal stores, but it did inhibit the influx of extracellular Ca2+ through its suppression of thromboxane A2 formation.