Dissociation in prefrontal cortex of affective and attentional shifts

  title={Dissociation in prefrontal cortex of affective and attentional shifts},
  author={Rebecca Dias and Trevor William Robbins and Angela C. Roberts},
THE prefrontal cortex is implicated in such human characteristics as volition, planning, abstract reasoning and affect1–6. Frontal-lobe damage can cause disinhibition such that the behaviour of a subject is guided by previously acquired responses that are inappropriate to the current situation7–9. Here we demonstrate that disinhibition, or a loss of inhibitory control, can be selective for particular cognitive functions and that different regions of the prefrontal cortex provide inhibitory… Expand
Inhibitory control and affective processing in the prefrontal cortex: neuropsychological studies in the common marmoset.
Exitotoxic lesion studies in marmosets comparing the effects of cell loss within specific regions of the prefrontal cortex on performance of a range of behavioural tests reveal that mechanisms of response inhibition are not unique to the orbitofrontal cortex. Expand
Dissociable mechanisms of attentional control within the human prefrontal cortex.
It is concluded that the antero-dorsal prefrontal cortex may be critical for higher order control of attention, whereas the postero-ventral area may be related to a lower level of shift, i.e. attentional set shifting. Expand
Integration of Cognitive and Motivational Information in the Primate Lateral Prefrontal Cortex
This review will discuss details of neuronal properties of LPFC neurons from the viewpoints of cognitive information processing and motivational information processing, and the question of how these two pieces of information are integrated. Expand
Dissociating executive functions of the prefrontal cortex.
  • T. Robbins
  • Psychology, Medicine
  • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 1996
Patients with frontal damage are shown to have deficits in their use of strategies to improve performance in a spatial working memory task and capacity to make an extra-dimensional shift due to a high-order failure of inhibition in an attentional set-shifting paradigm. Expand
Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates
It is anticipated that a greater understanding of the prefrontal cortex will come from using tasks that load specific cognitive and executive processes, in parallel with discovering new ways of manipulating the different sub-regions and neuromodulatory systems of the cortex. Expand
Perceptual Attentional Set-Shifting Is Impaired in Rats with Neurotoxic Lesions of Posterior Parietal Cortex
Rats with neurotoxic lesions of the PPC tested in an attentional set-shifting paradigm demonstrated a pattern of impairment identical to that of rats with medial frontal cortex lesions, suggesting that the interaction between the P PC and the frontal cortex is not limited to spatial attentional processing. Expand
Inefficiency in Self-organized Attentional Switching in the Normal Aging Population is Associated with Decreased Activity in the Ventrolateral Prefrontal Cortex
The findings reveal that, contrary to previous suggestions of a specific decrease in cognitive flexibility, older participants show no increased level of perseveration to either the recently rewarded object or the recently relevant object category. Expand
Double Dissociation of Attentional Resources: Prefrontal Versus Cingulate Cortices
Using lesion techniques and the rodent version of the Wisconsin card sorting task in humans, it is shown at least two types of attentional processing systems reside in the cingulate and prefrontal cortices depending on task demands requiring shifts of attention within or between sets of meaningful cues, respectively. Expand
Executive function and prefrontal cortex in rats
The term executive function describes a set of high-level abilities that influence more basic motor, sensory and mnemonic processes. These functions include working memory, behavioural flexibility,Expand
Double Dissociation of the Effects of Medial and Orbital Prefrontal Cortical Lesions on Attentional and Affective Shifts in Mice
It is demonstrated that an analog of the Wisconsin Card Sorting Test, developed in marmosets and recently adapted to rats, is a behavioral model of prefrontal function in mice, and formation of the attentional set in mice is dependent on the number of problem sets. Expand


6-Hydroxydopamine lesions of the prefrontal cortex in monkeys enhance performance on an analog of the Wisconsin Card Sort Test: possible interactions with subcortical dopamine
It is proposed that attentional set shifting is mediated by a balanced interaction between prefrontal and striatal dopamine, and that elevated dopamine contributes to the improvement in Attentional set-shifting ability. Expand
Contrasting mechanisms of impaired attentional set-shifting in patients with frontal lobe damage or Parkinson's disease.
The results suggest that the gross set-shifting deficits reported in both frontal lobe patients and patients with Parkinson's disease may involve fundamentally different, though related, cognitive processes, and that these may be differentially affected by medication. Expand
Monitoring of selections of visual stimuli and the primate frontal cortex
  • M. Petrides
  • Psychology, Medicine
  • Proceedings of the Royal Society of London. Series B: Biological Sciences
  • 1991
Findings delineate the mid-dorsolateral frontal cortex as a critical component of a neural system mediating the monitoring of self-generated responses in non-human primates as well as highlighting its importance in the recognition and recall of prior choices. Expand
The Prefrontal Cortex
The Prefrontal Cortex, Fifth Edition, provides users with a thoroughly updated version of this comprehensive work that has historically served as the classic reference on this part of the brain. TheExpand
Dissociation of object and spatial processing domains in primate prefrontal cortex.
These findings indicate that the prefrontal cortex contains separate processing mechanisms for remembering "what" and "where" an object is. Expand
Effects of Different Brain Lesions on Card Sorting: The Role of the Frontal Lobes
Sorting tasks, requiring the subject to respond selectively, first to one aspect of a situation and then to another, have traditionally been regarded as sensitive indicators of brain injury, butExpand
The problem of the frontal lobe: a reinterpretation.
  • W. Nauta
  • Psychology, Medicine
  • Journal of psychiatric research
  • 1971
To what extent the consequences of frontal-lobe lesion can be evaluated in neurological terms is inquired, and some aspects of this deficit in animals and man are reviewed. Expand
Descartes' error: emotion, reason, and the human brain. avon books
Descartes' Error offers the scientific basis for ending the division between mind and body. Antonio Damasio contends that rational decisions are not the product of logic alone - they require theExpand
The frontal lobes and voluntary action
The organization of the frontal lobe thought and voluntary action speech and basal ganglia are studied. Expand
Myelo‐ and cytoarchitecture of the granular frontal cortex and surrounding regions in the strepsirhine primate Galago and the anthropoid primate Macaca
As the first part of a comparative investigation of primate frontal cortex, we compared the frontal architectonic organization of Galago, a small‐brained, strepsirhine (or “prosimian”) primate, toExpand