Dissociation between the time course of ethanol and extracellular dopamine concentrations in the nucleus accumbens after a single intraperitoneal injection.

@article{Yim2000DissociationBT,
  title={Dissociation between the time course of ethanol and extracellular dopamine concentrations in the nucleus accumbens after a single intraperitoneal injection.},
  author={Hyunjune Yim and Donita L Robinson and Michael White and Justin Jaworski and Patrick K. Randall and Francine E. Lancaster and Rueben A. Gonzales},
  journal={Alcoholism, clinical and experimental research},
  year={2000},
  volume={24 6},
  pages={
          781-8
        }
}
BACKGROUND Dopamine release in the nucleus accumbens has been linked to the reinforcing effects of ethanol, but the time course or relationship of this response to ethanol concentrations in the brain has not been studied. METHODS Various doses of ethanol (0-2.0 g/kg) were administered intraperitoneally to male Sprague Dawley rats, and dopamine and ethanol were simultaneously analyzed in dialysate samples from the nucleus accumbens. A separate study to compare the ethanol-induced dopamine… CONTINUE READING

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