Dissociation between inhibition and killing by levofloxacin in human granulocytic anaplasmosis.

Abstract

Human granulocytic anaplasmosis (HGA) is a potentially fatal tick-borne infection caused by Anaplasma phagocytophilum. Treatment options are limited for this entity, with doxycycline being the drug of choice. Certain fluoroquinolones such as levofloxacin are active against A. phagocytophilum in vitro. We report a hospitalized patient with HGA who improved coincident with a 13-day course of levofloxacin therapy, but clinically and microbiologically relapsed 15 days after completion of treatment. Relapse of infection after levofloxacin therapy was reproduced in a severe combined immune-deficient (SCID) mouse infection model. Quinolone therapy should not be considered curative of HGA.

Cite this paper

@article{Wormser2006DissociationBI, title={Dissociation between inhibition and killing by levofloxacin in human granulocytic anaplasmosis.}, author={Gary P. Wormser and Alina Filozov and Sam Rountree Telford and Sandeepa Utpat and Russell S. Kamer and Dionysios Liveris and Guiqing Wang and Lois Zentmaier and Ira K Schwartz and Maria E. Aguero-Rosenfeld}, journal={Vector borne and zoonotic diseases}, year={2006}, volume={6 4}, pages={388-94} }