Dissociation between fat-induced in vivo insulin resistance and proximal insulin signaling in skeletal muscle in men at risk for type 2 diabetes.

@article{Storgaard2004DissociationBF,
  title={Dissociation between fat-induced in vivo insulin resistance and proximal insulin signaling in skeletal muscle in men at risk for type 2 diabetes.},
  author={Heidi Storgaard and Christine Bj\orn Jensen and Marie Bj{\"o}rnholm and Xiao Mei Song and Sten Madsbad and Juleen R Zierath and Allan Vaag},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2004},
  volume={89 3},
  pages={1301-11}
}
The effect of short- (2 h) and long-term (24 h) low-grade Intralipid infusion on whole-body insulin action, cellular glucose metabolism, and proximal components of the insulin signal transduction cascade was studied in seven obese male glucose intolerant first degree relatives of type 2 diabetic patients [impaired glucose tolerance (IGT) relatives] and eight matched control subjects. Indirect calorimetry and excision of vastus lateralis skeletal muscle biopsies were performed before and during… CONTINUE READING