Dissociation between behavioral effects and changes in metabolism of cerebral serotonin following δ9-tetrahydrocannabinol

@article{Gallager1972DissociationBB,
  title={Dissociation between behavioral effects and changes in metabolism of cerebral serotonin following δ9-tetrahydrocannabinol},
  author={Dorothy W. Gallager and Elaine sanders-Bush and Fridolin Sulser},
  journal={Psychopharmacologia},
  year={1972},
  volume={26},
  pages={337-345}
}
Behavioral changes, reaction times in analgesic tests and effects on metabolism of cerebral serotonin (5 HT) were monitored in male Sprague-Dawley rats following the administration ofδ 9-tetrahydrocannabinol (THC) as a propylene glycol-serum complex. THC (5.5 mg/kg i.p. and 1.0 mg/kg i.v.) produced characteristic and reproducible behavioral effects, including catalepsy and squealing, as well as significant increases in the reaction time as determined in both the hot plate and tail flick tests… CONTINUE READING
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