Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization.

  title={Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization.},
  author={Chistopher M. Counter and William C. Hahn and W Wei and Stephanie Dickinson Caddle and Roderick Leonardus Beijersbergen and Peter M. Lansdorp and John M. Sedivy and Robert A Weinberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={95 25},
The immortalization of human cells is a critical step during tumorigenesis. In vitro, normal human somatic cells must overcome two proliferative blockades, senescence and crisis, to become immortal. Transformation with viral oncogenes extends the life span of human cells beyond senescence. Such transformed cells eventually succumb to crisis, a period of widespread cellular death that has been proposed to be the result of telomeric shortening. We now show that ectopic expression of the… CONTINUE READING
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