Dissociation Between Fatty Liver and Insulin Resistance in Humans Carrying a Variant of the Patatin-Like Phospholipase 3 Gene

@inproceedings{Kantartzis2009DissociationBF,
  title={Dissociation Between Fatty Liver and Insulin Resistance in Humans Carrying a Variant of the Patatin-Like Phospholipase 3 Gene},
  author={Konstantinos Kantartzis and Andreas Peter and Fausto Machicao and J{\"u}rgen Machann and Silvia Wagner and Ingmar Koenigsrainer and Alfred Koenigsrainer and Fritz Schick and Andreas Fritsche and Hans-Ulrich H{\"a}ring and Norbert Stefan},
  booktitle={Diabetes},
  year={2009}
}
OBJECTIVE In a genome-wide association scan, the rs738409 C>G single nucleotide polymorphism (SNP) in the patatin-like phospholipase 3 gene (PNPLA3) was strongly associated with increased liver fat but not with insulin resistance estimated from fasting values. We investigated whether the SNP determines liver fat independently of visceral adiposity and whether it may even play a role in protecting from insulin resistance. RESEARCH DESIGN AND METHODS Liver fat was measured by (1)H magnetic… CONTINUE READING
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Arteriosclerosis, thrombosis, and vascular biology • 2008
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