Dissociating the long-term effects of fetal/neonatal iron deficiency on three types of learning in the rat.

  title={Dissociating the long-term effects of fetal/neonatal iron deficiency on three types of learning in the rat.},
  author={Adam T. Schmidt and Kelly J Waldow and William M. Grove and Juan A. Salinas and Michael K. Georgieff},
  journal={Behavioral neuroscience},
  volume={121 3},
Iron deficiency (ID) is a common nutrient deficiency worldwide. This condition is linked to changes in myelin formation, dopaminergic function, and energy metabolism. Early ID results in persistent long-term cognitive and behavioral disturbances in children, despite a return to normal iron status. The present study assesses formerly ID adult rats on maze learning tasks that depend on specific brain regions related to learning, specifically the hippocampus, striatum, and amygdala. Rat dams were… 

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Fetal and neonatal iron deficiency causes volume loss and alters the neurochemical profile of the adult rat hippocampus

Perinatal iron deficiency was associated with reduced hippocampal size and altered neurochemistry in adulthood, despite correction of brain iron deficiency, and the neurochemical changes suggest suppressed energy metabolism, neuronal activity, and plasticity in the formerly iron-deficient hippocampus.

Fetal–Neonatal Iron Deficiency Affects Neurotrophic Factor Expression, Neural Differentiation, and Neuroplasticity in the Rat Hippocampus

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Prenatal choline supplementation ameliorates the long-term neurobehavioral effects of fetal-neonatal iron deficiency in rats.

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The role of iron in learning and memory.

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Early-Life Iron Deficiency Anemia Alters the Development and Long-Term Expression of Parvalbumin and Perineuronal Nets in the Rat Hippocampus

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Novel data imply that alterations in the metabolite profile of the striatum likely influence later neural functioning in early iron deficiency, which is commonly in humans and results in altered behaviors suggestive of striatal dysfunction.

Perinatal nutritional iron deficiency permanently impairs hippocampus-dependent trace fear conditioning in rats

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Neonatal iron deficiency results in irreversible changes in dopamine function in rats.

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Iron deficiency decreases dopamine D1 and D2 receptors in rat brain

Long-term consequences of early iron deficiency in the rat

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Neurobehavioral analysis of developmental iron deficiency in rats