Dissociating the enhancing and inhibitory effects of pertussis toxin on autoimmune disease.

@article{Su2003DissociatingTE,
  title={Dissociating the enhancing and inhibitory effects of pertussis toxin on autoimmune disease.},
  author={Shao Bo Su and Phyllis B. Silver and Peng Wang and C. -K. Chan and Rachel R Caspi},
  journal={Journal of immunology},
  year={2003},
  volume={171 5},
  pages={2314-9}
}
Pertussis toxin (PT) has both enhancing and inhibitory effects on experimental autoimmune disease, depending on its time of administration relative to immunization. The inhibitory effect is due to blocking of G(i)-coupled receptors by the enzymatic A subunit. In this study, we attribute the enhancing effect of PT to the cell-binding B subunit (PT-B). C57BL/6 mice, a strain that requires PT to develop experimental uveitis, were immunized with a retinal Ag and were injected with whole PT, PT-B… CONTINUE READING