Dissociating nociceptive modulation by the duration of pain anticipation from unpredictability in the timing of pain

@article{Clark2008DissociatingNM,
  title={Dissociating nociceptive modulation by the duration of pain anticipation from unpredictability in the timing of pain},
  author={Jennifer A. Clark and Christopher Andrew Brown and A. K. Jones and Wael El-Deredy},
  journal={Clinical Neurophysiology},
  year={2008},
  volume={119},
  pages={2870-2878}
}
OBJECTIVE Waiting longer to receive pain increases its perceived unpleasantness by inducing 'dread'. However, it is not clear how unpredictability in the timing of the impending pain stimulus interacts with dread and whether the two factors show differential effects on the neural generators of the pain-evoked response. METHODS We manipulated the duration of anticipation of laser-induced pain independently of unpredictability of stimulus delivery timing, to observe the relative effect on P2… CONTINUE READING

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