Dissociated thyromimetic effects of 3, 5, 3'-triiodothyroacetic acid (TRIAC) at the pituitary and peripheral tissue levels.

@article{BeckPeccoz1988DissociatedTE,
  title={Dissociated thyromimetic effects of 3, 5, 3'-triiodothyroacetic acid (TRIAC) at the pituitary and peripheral tissue levels.},
  author={Paolo Beck-Peccoz and Alessandro Sartorio and Clotilde De Medici and Graziano Grugni and Francesco Morabito and Giovanni Faglia},
  journal={Journal of endocrinological investigation},
  year={1988},
  volume={11 2},
  pages={113-8}
}
Although TRIAC is bound at least twice as avidly to nuclear receptor as T3, its thyromimetic potency is relatively low and its effect at the pituitary level on thyrotropin (TSH) secretion seems to be dissociated from that at the peripheral tissue level. In order to gain further insight into the complex effects of this thyroid hormone analog, we studied the… CONTINUE READING