Dissociated overexpression of cathepsin D and estrogen receptor alpha in preinvasive mammary tumors.

@article{Roger2000DissociatedOO,
  title={Dissociated overexpression of cathepsin D and estrogen receptor alpha in preinvasive mammary tumors.},
  author={Pascal Roger and J. P. Daur{\`e}s and Thierry Maudelonde and Christine Pignodel and Michel Gleizes and J A Chapelle and Christiane Marty-Double and Pierre Baldet and Pierre Mares and François Laffargue and Henri Rochefort},
  journal={Human pathology},
  year={2000},
  volume={31 5},
  pages={593-600}
}
The role of estrogen as a promoter agent of sporadic breast cancer has been considered by assaying, in benign breast disease (BBD) and in situ carcinomas (CIS), 2 markers, the estrogen receptor alpha (ERalpha) and cathepsin D (cath-D) involved in estrogen action on mammary tissue. ERalpha and cath-D were assayed by quantitative immunohistochemistry using an image analyzer in 170 lesions of varying histological risk (94 BBD and 76 CIS), and in "normal" glands close to these lesions. The ERalpha… CONTINUE READING
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