Dissociable roles of mGlu5 and dopamine receptors in the rewarding and sensitizing properties of morphine and cocaine

@article{Veeneman2010DissociableRO,
  title={Dissociable roles of mGlu5 and dopamine receptors in the rewarding and sensitizing properties of morphine and cocaine},
  author={Maartje M J Veeneman and Hetty Boleij and Mark H. Broekhoven and Eelke Mirthe Simone Snoeren and M. Guitart Masip and J. Cousijn and Will Spooren and Louk J.M.J. Vanderschuren},
  journal={Psychopharmacology},
  year={2010},
  volume={214},
  pages={863 - 876}
}
RationaleDrugs of abuse are initially used because of their rewarding properties. As a result of repeated drug exposure, sensitization to certain behavioral effects of drugs occurs, which may facilitate the development of addiction. Recent studies have implicated the metabotropic glutamate receptor 5 (mGlu5 receptor) in drug reward, but its role in sensitization is unclear. Stimulation of dopamine receptors plays an important role in drug reward, but not in the sensitizing properties of cocaine… 
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