Dissociable regulation of instrumental action within mouse prefrontal cortex.

@article{Gourley2010DissociableRO,
  title={Dissociable regulation of instrumental action within mouse prefrontal cortex.},
  author={Shannon L Gourley and Anni S Lee and Jessica L. Howell and Christopher Pittenger and Jane Rebecca Taylor},
  journal={The European journal of neuroscience},
  year={2010},
  volume={32 10},
  pages={1726-34}
}
Evaluation of the behavioral 'costs', such as effort expenditure relative to the benefits of obtaining reward, is a major determinant of goal-directed action. Neuroimaging evidence suggests that the human medial orbitofrontal cortex (mOFC) is involved in this calculation and thereby guides goal-directed and choice behavior, but this region's functional significance in rodents is unknown despite extensive work characterizing the role of the lateral OFC in cue-related response inhibition… CONTINUE READING

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