Dissociable effects of noradrenaline, dopamine, and serotonin uptake blockade on stop task performance in rats

@article{Bari2009DissociableEO,
  title={Dissociable effects of noradrenaline, dopamine, and serotonin uptake blockade on stop task performance in rats},
  author={Andrea Bari and Dawn M. Eagle and A. C. Du Mar and Emma S J Robinson and T W Robbins},
  journal={Psychopharmacology},
  year={2009},
  volume={205},
  pages={273 - 283}
}
RationaleThe stop-signal paradigm measures the ability to stop a motor response after its execution has been initiated. Impairments in inhibiting inappropriate behavior and prolonged stop-signal reaction times (SSRTs) are characteristic of several psychiatric disorders, most notably attention deficit/hyperactivity disorder. While there is relative consensus regarding the anatomical substrates of behavioral inhibition, the neurochemical imbalance responsible for the deficits in stopping… CONTINUE READING

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