Dissociable effects of NR2A and NR2B NMDA receptor antagonism on cognitive flexibility but not pattern separation

@article{Kumar2015DissociableEO,
  title={Dissociable effects of NR2A and NR2B NMDA receptor antagonism on cognitive flexibility but not pattern separation},
  author={G. S. Yashavanth Kumar and Joseph Olley and Thomas Steckler and John C. Talpos},
  journal={Psychopharmacology},
  year={2015},
  volume={232},
  pages={3991-4003}
}
N-methyl-d-aspartate (NMDA) receptors play crucial roles in learning and memory, but the role of each NMDA receptor subtype in a specific cognitive process is unclear. Non-selective blockers of NMDA receptor are used to model the cognitive impairment in schizophrenia and Alzheimer’s disease. Counter-intuitively selective NR2A and 2B NMDA receptor antagonists are thought to have pro-cognitive properties. These seemingly contrasting findings might in part be the result of different compounds and… CONTINUE READING
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