Dissociable cortico-striatal connectivity abnormalities in major depression in response to monetary gains and penalties

  title={Dissociable cortico-striatal connectivity abnormalities in major depression in response to monetary gains and penalties},
  author={Roee Admon and Lisa D. H. Nickerson and Daniel G. Dillon and Avram J. Holmes and Ryan Bogdan and P. Kumar and Darin D. Dougherty and Dan V. Iosifescu and David Mischoulon and Maurizio Fava and Diego A. Pizzagalli},
  journal={Psychological Medicine},
  pages={121 - 131}
Background Individuals with major depressive disorder (MDD) are characterized by maladaptive responses to both positive and negative outcomes, which have been linked to localized abnormal activations in cortical and striatal brain regions. However, the exact neural circuitry implicated in such abnormalities remains largely unexplored. Method In this study 26 unmedicated adults with MDD and 29 matched healthy controls (HCs) completed a monetary incentive delay task during functional magnetic… 
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Reductions in Cortico-Striatal Hyperconnectivity Accompany Successful Treatment of Obsessive-Compulsive Disorder with Dorsomedial Prefrontal rTMS
Reductions in fronto-striatal hyperconnectivity were associated with treatment response to dmPFC-rTMS in OCD, consistent with previous fMRI studies of deep brain stimulation in OCD but opposite to previous reports on mechanisms of dm PFC- rT MS in major depression.
Modulation of anterior cingulate cortex reward and penalty signalling in medication-naive young-adult subjects with depressive symptoms following acute dose lurasidone
Lurasidone acutely normalises reward processing signals in individuals with depressive symptoms in a double-blind placebo-controlled cross-over study to examine how a novel D2 antagonist with adjunctive antidepressant properties modifies activity in the brain's reward network in depression.
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Examination of the relationships between reward processing and response to antidepressant treatment using clinical, behavioral, and functional neuroimaging measures concluded that escitalopram response is associated with clinical and neuroim imaging correlates of reward processing.


Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder.
Results suggest that basal ganglia dysfunction in major depression may affect the consummatory phase of reward processing, and morphometric results suggest that anhedonia in major Depression is related to caudate volume.
Relationships between changes in sustained fronto-striatal connectivity and positive affect in major depression resulting from antidepressant treatment.
Treatment-induced change in the sustained engagement of fronto-striatal circuitry tracks the experience of positive emotion in daily life and studies examining reduced positive affect in a variety of psychiatric disorders might benefit from examining the temporal dynamics of brain activity.
Spatiotemporal dynamics of error processing dysfunctions in major depressive disorder.
Unmedicated patients with major depressive disorder showed reduced accuracy and potentiated error-related negativity immediately after committing errors, highlighting dysfunctions in the automatic detection of unfavorable performance outcomes.
Limbic-cortical dysregulation: a proposed model of depression.
  • H. Mayberg
  • Psychology, Biology
    The Journal of neuropsychiatry and clinical neurosciences
  • 1997
A working model of depression implicating failure of the coordinated interactions of a distributed network of limbic-cortical pathways is proposed to facilitate continued integration of clinical imaging findings with complementary neuroanatomical, neurochemical, and electrophysiological studies in the investigation of the pathogenesis of affective disorders.
Altered striatal activation predicting real-world positive affect in adolescent major depressive disorder.
Results support models of altered reward processing and related positive affect in young people with major depressive disorder and indicate that depressed adolescents' brain response to monetary reward is related to their affective experience in natural environments, suggesting that reward-processing paradigms capture brain function relevant to real-world positive affect.
Neural Responses to Monetary Incentives in Major Depression
Reduced capacity to sustain positive emotion in major depression reflects diminished maintenance of fronto-striatal brain activation
The hypothesis that anhedonia in depressed patients reflects the inability to sustain engagement of structures involved in positive affect and reward is supported.
fMRI of alterations in reward selection, anticipation, and feedback in major depressive disorder.
Resting anterior cingulate activity and abnormal responses to errors in subjects with elevated depressive symptoms: A 128‐channel EEG study
The hypothesized abnormal reactions to error would be associated with dysfunctional rostral ACC activity, a region previously implicated in error detection and evaluation of the emotional significance of events, and these findings provide initial insight into putative mechanisms fostering treatment response.