Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity.

@article{Ishigaki2005DissipatingEE,
  title={Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity.},
  author={Yasushi Ishigaki and Hideki Katagiri and Tetsuya Yamada and Takehide Ogihara and Junta Imai and Kenji Uno and Yutaka Hasegawa and Junhong Gao and Hisamitsu Ishihara and Tooru Shimosegawa and Hideyuki Sakoda and Tomoichiro Asano and Yoshitomo Oka},
  journal={Diabetes},
  year={2005},
  volume={54 2},
  pages={322-32}
}
For examining whether dissipating excess energy in the liver is a possible therapeutic approach to high-fat diet-induced metabolic disorders, uncoupling protein-1 (UCP1) was expressed in murine liver using adenoviral vectors in mice with high-fat diet-induced diabetes and obesity, and in standard diet-fed lean mice. Once diabetes with obesity developed, hepatic UCP1 expression increased energy expenditure, decreased body weight, and reduced fat in the liver and adipose tissues, resulting in… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Bach1 deficiency protects pancreatic β-cells from oxidative stress injury.

American journal of physiology. Endocrinology and metabolism • 2013

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Possible physiological roles of mitochondrial uncoupling proteins--UCPn.

The international journal of biochemistry & cell biology • 2002

Similar Papers

Loading similar papers…