Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin

@article{Hiramatsu1997DisseminationIJ,
  title={Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin},
  author={Keiichi Hiramatsu and Nanae Aritaka and Hideaki Hanaki and Shiori Kawasaki and Intetsu Kobayashi},
  journal={The Lancet},
  year={1997},
  volume={350},
  pages={1670-1673}
}
BACKGROUND Since the discovery of the vancomycin-resistant Staphylococcus aureus (VRSA) strain Mu50 (minimum inhibitory concentration [MIC] 8 mg/L), there has been concern about the potential spread of such strains throughout Japanese hospitals. Two important questions need to be answered: (1) what is the prevalence of VRSA, and (2) by what mechanism does vancomycin resistance occur. METHODS The vancomycin susceptibilities of three methicillin-resistant S aureus (MRSA) strains (Mu50, Mu3, and… CONTINUE READING

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